Hypersensitivity. Patients w/ history, symptoms, or signs of ischemic cardiac, cerebrovascular, or peripheral vascular syndromes, valvular heart disease or cardiac arrhythmias (especially tachycardias); other significant underlying CV diseases (eg, atherosclerotic disease, congenital heart disease); uncontrolled or severe HTN; hemiplegic, basilar, or ophthalmoplegic migraine. Concurrent administration of MAOI or use w/in 2 wk of discontinuation of MAOI therapy. Use w/in 24 hr before or after treatment w/ other 5-HT
1 receptor agonists, or ergotamine-containing drugs or their derivatives (eg, dihydroergotamine, methysergide). Should not be administered to patients w/ severe hepatic impairment.