Tezspire Dosage/Direction for Use

Treatment should be initiated by physicians experienced in the diagnosis and treatment of severe asthma.
Posology: Adults and adolescents (aged 12 years and older): The recommended dose is 210 mg of tezepelumab by subcutaneous injection every 4 weeks.
Tezspire is intended for long-term treatment. A decision to continue the therapy should be made at least annually based on the patient's level of asthma control.
Missed dose: If a dose is missed, the dose should be administered as soon as possible. Thereafter, the patient can resume dosing on the scheduled day of administration. If the next dose is already due, then administer as planned. A double dose must not be administered.
Special populations: Elderly (≥ 65 years of age): No dose adjustment is required for elderly patients (see Pharmacology: Pharmacokinetics under Actions).
Renal and hepatic impairment: No dose adjustment is required for patients with renal or hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).
Paediatric population: The safety and efficacy of Tezspire in children under 12 years of age have not been established. No data are available.
Method of administration: Tezspire is administered as a subcutaneous injection.
A patient may self-inject or the patient's caregiver may administer this medicinal product after training in subcutaneous injection technique. Proper training should be provided to patients and/or caregivers on the preparation and administration of Tezspire prior to use according to the 'Instructions for Use'.
Tezspire should be injected into the thigh or abdomen, except for the 5 cm around the navel. If a healthcare professional or caregiver administers the injection, the upper arm can also be used. A patient should not self-inject in the arm. It should not be injected into areas where the skin is tender, bruised, erythematous, or hardened. It is recommended to rotate the injection site with each injection.
Comprehensive instructions for administration using the pre-filled pen is provided in the 'Instructions for Use'.