Theophylline, ritonavir & high-fat meal alter clearance, exposure & plasma conc of cetirizine. Allergy tests inhibited by antihistamines. Concomitant use of sympathomimetic amines & MAOI can result in hypertensive crisis. Caution w/ methyldopa, guanethidine & reserpine. Linezolid w/ pseudoephedrine. Sympathomimetic drugs eg, decongestants (eg, phenylpropanolamine, phenylephrine, ephedrine), appetite suppressants, psychostimulants eg, amphetamines, antihypertensive drugs (reduction of antihypertensive effects), bromocriptine, pergolide, lisuride, cabergoline, ergotamine, TCAs, alcohol or other CNS depressants, cardiac glycosides eg, digoxin or digitoxin, NSAIDs. Antacids & proton pump inhibitors increase the rate of pseudoephedrine absorption; kaolin decreases it. Concurrent use w/ halogenated anaesth agents may provoke or worsen ventricular arrhythmia.
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