Oral
Upper respiratory tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 250-1,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Oral
Lower respiratory tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 250-1,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Oral
Urinary tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 500 mg 6 or 8 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Oral
Gonorrhoea
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. In combination with probenecid: 2,000 mg as a single dose; repeated doses are recommended in females. Consideration must be given to local treatment guidelines.
Child: Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Oral
Gastrointestinal infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 500-750 mg tid to 4 times daily. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Oral
Typhoid fever
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 1,000-2,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Oral
Paratyphoid fever
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. 1,000-2,000 mg 6 hourly. Consideration must be given to local treatment guidelines.
Child: Usual dose range: 50-100 mg/kg daily in divided doses 6 hourly. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Parenteral
Bacterial meningitis
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 8,000-14,000 mg daily or 150-200 mg/kg daily in divided doses 3-4 hourly. May give initial treatment via slow IV inj for at least 3 days and continued with deep IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Infants and children Usual dose range: 100-200 mg/kg daily in divided doses 3-4 hourly; may give initial treatment via IV for 3 days and continue with IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).
Parenteral
Septicaemia
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 8,000-14,000 mg daily or 150-200 mg/kg daily in divided doses 3-4 hourly. May give initial treatment via slow IV inj for at least 3 days and continued with deep IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Infants and children Usual dose range: 100-200 mg/kg daily in divided doses 3-4 hourly; may give initial treatment via IV for 3 days and continue with IM inj. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).
Parenteral
Gastrointestinal infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).
Parenteral
Urinary tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly; via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 50-100 mg/kg daily in divided doses 6 hourly via slow IV inj or IV infusion, or via deep IM inj; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).
Parenteral
Endocarditis
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).
Parenteral
Respiratory tract infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).
Parenteral
Intra-abdominal infections
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).
Parenteral
Peritonitis
Adult: Dosage is individualised based on the type or severity of the infection, the age, and renal function of the patient. Usual dose range: 500 mg 4-6 hourly via slow IV inj or IV infusion, or via deep IM inj; may give higher doses in severe cases. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: Usual dose range: ≤40 kg: 25-50 mg/kg daily in divided doses 6 hourly; >40 kg: Same as adult dose. Treatment and dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Renal impairment: Haemodialysis patient: Give a supplemental dose after each dialysis period (refer to specific product guidelines).
CrCl (ml/min) | Dosage Recommendation |
<10 | Reduction in dose or increase of dose interval may be required (refer to specific product guidelines). |
Reconstitution: Adults and children: IV inj or infusion: Dilute with appropriate amount of sterile water for inj, NaCl 0.9% solution, dextrose 5% in water solution or Ringer's solution to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 125 mg/mL or 250 mg/mL. Neonates: IV inj or infusion: Reconstitute a vial with the labelled amount of sterile water for inj. Further dilute the reconstituted solution with NaCl 0.9% solution or other compatible diluents to prepare the desired concentration. IM inj: Reconstitute vial with the appropriate amount of sterile water for inj to make a final concentration of 250 mg/mL. Do not use bacteriostatic water for inj as a diluent for IV/IM inj. Instructions for reconstitution and stability recommendations may vary among individual products and between countries (refer to specific product guidelines).
Incompatibility: IV/IM: Incompatible with blood products, protein hydrolysates, or IV lipid emulsions; aminoglycosides (in same syringe, IV fluid container or giving set); metronidazole, and tetracycline derivatives inj (e.g. oxytetracycline, rolitetracycline, doxycycline).