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Administration
May be taken with or without food.
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Contraindications
As monotherapy in pre-menopausal women with breast cancer. Severe renal impairment (CrCl <20 mL/min). Pregnancy and lactation.
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Special Precautions
Patient with hyperlipidaemia; pre-existing osteopenia, ischaemic cardiac disease. Moderate to severe hepatic or mild to moderate renal impairment. Patient Counselling This drug may cause asthenia and somnolence, if affected, do not drive or operate machinery. Monitoring Parameters Perform pregnancy test prior to initiation of treatment in women with child-bearing potential. Monitor BMD, total cholesterol, LDL, CNS changes, hypotension, thrombophlebitis, bone pain or fracture at regular intervals during therapy.
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Adverse Reactions
Significant: Decreased BMD (e.g. osteoporosis), hypercholesterolaemia, hypersensitivity reactions (e.g. anaphylaxis, angioedema, urticaria), ischaemic heart disease.
Blood and lymphatic system disorders: Lymphoedema.
Cardiac disorders: Angina pectoris, dyspnoea, chest pain.
Eye disorders: Cataract.
Gastrointestinal disorders: Gastrointestinal distress, anorexia, nausea, vomiting, constipation, diarrhoea, abdominal pain, dyspepsia, gastrointestinal disease, xerostomia.
General disorders and administration site conditions: Fatigue, pain, weakness.
Injury, poisoning and procedural complications: Bone fracture, accidental injury.
Investigations: Weight gain.
Metabolism and nutrition disorders: Oedema.
Musculoskeletal and connective tissue disorders: Arthritis, myalgia, arthralgia, back pain, ostealgia.
Nervous system disorders: Headache, dizziness, paraesthesia, carpal tunnel syndrome.
Psychiatric disorders: Mood disorder, depression, insomnia, anxiety.
Renal and urinary disorders: UTI.
Reproductive system and breast disorders: Pelvic pain, mastalgia, vulvovaginitis, vaginal dryness or bleeding.
Respiratory, thoracic and mediastinal disorders: Pharyngitis, cough, flu-like symptoms, sinusitis.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Vasodilation, hypertension, hot flushes.
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Drug Interactions
Diminished therapeutic effect with oestrogen derivatives. Decreased serum concentration with tamoxifen.
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CIMS Class
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ATC Classification
L02BG03 - anastrozole ; Belongs to the class of enzyme inhibitors. Used in endocrine therapy.
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