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Contraindications
Patient w/ resp or CNS depression, neuropsychiatric problems, or dementia. Patient who has "on" response to levodopa marred by severe dyskinesia or dystonia.
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Special Precautions
Patient prone to nausea and vomiting or when vomiting is likely to pose a risk. Patient w/ pulmonary, CV, or endocrine disease, history of orthostatic hypotension. Renal and hepatic impairment. Elderly or debilitated patients. Pregnancy and lactation. Patient Counselling This drug may cause somnolence and/or an episode of sudden sleep onset, if affected do not drive or operate machinery. Monitoring Parameters Periodic monitoring of hepatic, renal, haematopoietic, and CV function.
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Adverse Reactions
Yawning, dyskinesias, nausea and/or vomiting, somnolence, transient sedation, dizziness, oedema, chest pain, orthostatic hypotension, postural instability and falls, increased salivation and perspiration, neuropsychiatric disturbances. Signs of CNS stimulation (e.g. euphoria, lightheadedness, restlessness, tremor, tachycardia and tachypnoea). Induration, nodule formation, and panniculitis, sometimes leading to ulceration, often develops at the site of inj. Rarely, eosinophilia.
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Drug Interactions
May potentiate hypotensive effects of antihypertensives or organic nitrates. Antipsychotics and other drugs that act as CNS dopamine inhibitors may antagonise therapeutic effects of apomorphine. Additive effect on QT interval prolongation w/ drugs known to prolong the QT interval (e.g. TCAs, antipsychotic agents). May enhance effect w/ memantine and entacapone.
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CIMS Class
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ATC Classification
N04BC07 - apomorphine ; Belongs to the class of dopamine agonist. Used in the management of Parkinson's disease.
G04BE07 - apomorphine ; Belongs to the class of drugs used in erectile dysfunction. |
