Brimonidine

Childn <2 yr. Concomitant use of MAOIs.

Patient w/ severe or unstable and uncontrolled CV disease, mental depression, orthostatic hypotension, cerebral or coronary insufficiency, Raynaud's phenomenon, or thromboangiitis obliterans. Renal or hepatic impairment. Patient Counselling This drug may cause fatigue and/or drowsiness, if affected, do not drive or operate machinery. Avoid exposure to excessive sunlight and UV irradiation (topical). Remove contact lenses prior to ophth admin and reinsert after 15 min. Monitoring Parameters Monitor IOP routinely.

Erythema, pruritus, flushing, burning sensation, paraesthesia. nasopharyngitis, increased IOP, contact dermatitis, skin irritation, dry skin, acne, papular rash, worsening of rosacea, pain of skin, warm skin, swelling face, nasal congestion, angioedema, peripheral coldness, upper resp tract infection (topical). Ocular hyperaemia, burning/ stinging sensation, blurred vision, ocular allergic reaction, conjunctival follicles, corneal staining/erosion, photophobia, eyelid erythema, ocular dryness, ocular pain, conjunctival blanching, conjunctival discharge, iritis, iridocyclitis, miosis, fatigue, drowsiness, dizziness, asthenia, abnormal taste, blepharitis, depression, nasal dryness, palpitation, arrhythmias, hypotension, syncope, headache, blurred vision, dry mouth, eyelid oedema (ophth).

TCAs (e.g. imipramine) and tetracyclic antidepressants (e.g. mianserin) that affect the metabolism and uptake of circulating amines may interfere w/ IOP-lowering effect brimonidine. Additive IOP-lowering and CV effects w/ β-blockers, antihypertensives, cardiac glycosides. Additive or potentiating effect w/ CNS depressants (e.g. barbiturates, opiates, sedatives or anaesthetics).

Antiglaucoma Preparations / Other Dermatologicals

S01GA07 - brimonidine
D11AX21 - brimonidine ; Belongs to the class of other dermatologicals.
S01EA05 - brimonidine ; Belongs to the class of sympathomimetics used in the treatment of glaucoma.