Cefuroxime

Cefuroxime: May be taken with or without food.
Cefuroxime: Should be taken with food.

Hypersensitivity to cefuroxime or any other cephalosporins.

Patient with a penicillin or other beta-lactam allergy; history of colitis, history of seizure disorder. Patient taking potent diuretics (e.g. furosemide) and aminoglycosides. Renal impairment. Children and elderly. Pregnancy and lactation. Cefuroxime axetil tab and granules for oral susp are not bioequivalent and are not substitutable on a mg-per-mg basis. Patient counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor renal, hepatic and haematologic function periodically during prolonged treatment. Monitor prothrombin time in patients at risk of prolongation (e.g. nutritionally-deficit, prolonged therapy, renal or hepatic impairment). Observe for signs and symptoms of anaphylaxis during 1st dose. Perform culture and sensitivity tests and consult local recommendations before treatment initiation due to antibiotic resistance risks.

Significant: Elevated INR (in nutritionally deficient patients; renal or hepatic disease, prolonged use), bacterial or fungal superinfection with prolonged use, including Clostridium difficile-associated diarrhoea and pseudomembranous colitis; Jarisch-Herxheimer reaction (following treatment of Lyme disease). Blood and lymphatic system disorders: Neutropenia, eosinophilia, decreased Hb, leucopenia, thrombocytopenia. Gastrointestinal disorders: Diarrhoea, nausea, vomiting, abdominal pain. General disorders and administration site conditions: Inj site reaction (e.g. pain, thrombophlebitis). Investigations: Transient increase of hepatic enzyme levels. Nervous system disorders: Headache, dizziness. Skin and subcutaneous tissue disorders: Skin rash, urticaria, pruritus.
Potentially Fatal: Severe hypersensitivity (anaphylactic) reactions.

Increased serum concentration with probenecid. May reduce the efficacy of estrogen/progesterone oral contraceptives.

Cephalosporins

S01AA27 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the treatment of eye infections.
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.