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Administration
Should be taken with food. Take during meals.
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Contraindications
Hypersensitivity to chlortalidone and other sulfonamide derivatives. Anuria, symptomatic hyperuricaemia (i.e. history of gout or uric acid calculi); refractory hypokalaemia, hyponatraemia, and hypercalcaemia; adrenal insufficiency (e.g. Addison's disease), HTN during pregnancy. Severe hepatic or renal (CrCl <30 mL/min) impairment. Concomitant lithium therapy.
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Special Precautions
Patient w/ DM, moderate-high cholesterol level, SLE, history of allergy or bronchial asthma. Patient undergoing surgery. Childn, elderly. Hepatic (e.g. cirrhosis) or renal (e.g. nephrotic syndrome) impairment. Pregnancy and lactation. Patient Counselling This drug can cause dizziness, if affected, do not drive or operate machinery. Avoid long-term sun exposure. Monitoring Parameters Monitor BP, serum electrolytes, renal function, wt, and intake/output records (daily to determine fluid loss).
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Adverse Reactions
Significant: Hypersensitivity, hypokalaemia, hyperlipidaemia, hyperuricaemia, hyponatraemia, hypomagnesaemia, hypochloremic alkalosis, hyperglycaemia, gout, photosensitivity. Rarely, hypercalcaemia.
Nervous: Dizziness, vertigo.
CV: Postural hypotension.
GI: Mild GI disturbance, loss of appetite.
Genitourinary: Erectile dysfunction.
Dermatologic: Rash, urticaria.
Others: Weakness.
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Drug Interactions
Increased hypokalaemic effect w/ corticosteroids, amphotericin, carbenoxolone, ACTH, and β2-agonists. Reduced diuretic and antihypertensive effects w/ NSAIDs (e.g. indometacin). May increase the effects of antihypertensive agents and curare derivatives. May reduce therapeutic effects of insulin, oral antidiabetic agents, and oral anticoagulants. May induce cardiac arrhythmia w/ digitalis. May increase risk of hyperuricaemia and gout-type complications w/ ciclosporin.
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CIMS Class
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ATC Classification
C03BA04 - chlortalidone ; Belongs to the class of low-ceiling sulfonamide diuretics.
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