Cyproheptadine

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Angle-closure glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, bladder neck obstruction or predisposition to urinary retention. Patient undergoing treatment for acute asthmatic attack. Newborn or premature infants; elderly and debilitated patients. Lactation. Concomitant use with MAOIs.

Patient with CV disease, including hypertension and ischaemic heart disease; thyroid dysfunction (e.g. hyperthyroidism), history of bronchial asthma, other chronic breathing disorders; increased intraocular pressure, acute porphyria. Hepatic impairment. Children (≥2 years). Pregnancy. Patient Counselling This drug may cause dizziness, drowsiness, or sedation; if affected, do not drive or operate machinery. Monitoring Parameters Monitor weight periodically; excess anticholinergic effects at the start of treatment and periodically thereafter.

Significant: CNS depression (e.g. dizziness, sedation), hypotension; excitation (in children). Blood and lymphatic system disorders: Rarely, blood dyscrasias in prolonged use (e.g. leucopenia, haemolytic anaemia, agranulocytosis, thrombocytopenia). Cardiac disorders: Palpitation, extrasystoles, tachycardia. Ear and labyrinth disorders: Tinnitus, vertigo, acute labyrinthitis. Eye disorders: Blurred vision, diplopia. Gastrointestinal disorders: Dry mouth, nausea, vomiting, diarrhoea, constipation, epigastric distress. General disorders and administration site conditions: Fatigue, rigors. Hepatobiliary disorders: Jaundice, hepatitis, cholestasis, hepatic failure. Immune system disorders: Allergic reactions (e.g. rash, oedema), anaphylactic shock. Investigations: Weight gain, abnormal hepatic function. Metabolism and nutrition disorders: Increased appetite, anorexia. Nervous system disorders: Drowsiness, headache, tremor, restlessness, paraesthesia, convulsion, disturbed coordination, neuritis. Psychiatric disorders: Confusion, insomnia, nervousness, hallucination, euphoria, irritability, aggressive behaviour, hysteria. Renal and urinary disorders: Urinary retention, frequency or difficulty in micturition. Reproductive system and breast disorders: Early menses. Respiratory, thoracic and mediastinal disorders: Dry nose and throat, chest tightness and wheezing, nasal stuffiness, epistaxis, thickened bronchial secretion. Skin and subcutaneous tissue disorders: Photosensitivity, urticaria, increased sweating.

Additive effects with other CNS depressants (e.g. sedatives, hypnotics, tranquillisers, antianxiety drugs). May interfere with serotonin-enhancing antidepressants (e.g. SSRI) which may result in recurrence of depression and related symptoms.

Antihistamines & Antiallergics / Antimigraine Preparations / Appetite Enhancers

R06AX02 - cyproheptadine ; Belongs to the class of other antihistamines for systemic use.