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Contraindications
Hypersensitivity. Patient w/ varicella or herpes zoster infection.
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Special Precautions
Patient w/ impaired bone marrow. Renal and hepatic impairment. Pregnancy and lactation. Patient Counselling Avoid inhalation of vapours or contact w/ skin, mucous membrane or eyes. Monitoring Parameters Monitor blood counts, renal, hepatic and bone marrow functions frequently.
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Adverse Reactions
Nausea, vomiting, cheilitis, oesophagitis, GI ulceration, proctitis, fever, malaise, hypocalcaemia, myalgia, alopecia, pneumonitis, kidney and liver abnormalities, eruptions, acne, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, severe tissue damage, oedema, neutropenia and febrile neutropenia.
Potentially Fatal: Hepatic failure, hepatic veno-occlusive disease, particularly in childn <4 yr, myelosuppression, sepsis, including neutropenic sepsis. |
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Drug Interactions
Combination w/ radiation therapy may result in increased toxicity esp when w/in 2 mth of radiation treatment for right-sided Wilm's tumour. May diminish the therapeutic effect of live vaccines.
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CIMS Class
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ATC Classification
L01DA01 - dactinomycin ; Belongs to the class of cytotoxic antibiotics, actinomycines. Used in the treatment of cancer.
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