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Administration
May be taken with or without food.
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Contraindications
Cardiac insufficiency w/ ongoing diuretic treatment. Patient w/ habitual and psychogenic polydipsia, hyponatraemia or history of hyponatraemia. Moderate to severe renal impairment (CrCl <50 mL/min).
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Special Precautions
Patient w/ CV disease or cystic fibrosis, coronary artery insufficiency, at risk for increased intracranial pressure, predisposed to thrombus formation. Elderly and childn. Pregnancy and lactation. Monitoring Parameters Monitor BP and pulse during IV infusion.
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Adverse Reactions
Headache, nausea, stomach pain, allergic skin reaction and more severe general allergic reactions, cerebral or coronary thrombosis. Local irritation, congestion and epistaxis. Pain and swelling at the inj site.
Potentially Fatal: Anaphylaxis. |
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Drug Interactions
May enhance antidiuretic effect w/ NSAIDs (e.g. ibuprofen), indometacin, TCAs, chlorpromazine, carbamazepine, SSRIs, opiates, lamotrigine. May reduce antidiuretic effect w/ lithium, epinephrine (large dose), heparin, demeclocycline.
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CIMS Class
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ATC Classification
H01BA02 - desmopressin ; Belongs to the class of vasopressin and analogues. Used in posterior pituitary lobe hormone preparations.
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