|
Administration
Should be taken with food. Take w/ or immediately after meals.
|
|
Contraindications
Hypersensitivity to anthraquinone derivatives. Inflammatory intestinal disease (e.g. ulcerative colitis, Crohn's disease), intestinal obstruction, painful abdominal syndromes of undetermined cause. Severe renal and hepatic impairment. Concomitant use with laxatives.
|
|
Special Precautions
Patient with previous episode of enterocolic disturbances (e.g. irritable bowel syndrome). Elderly. Moderate renal and mild to moderate hepatic impairment. Pregnancy and lactation.
|
|
Adverse Reactions
Significant: Diarrhoea.
Gastrointestinal disorders: Abdominal pain, flatulence.
Hepatobiliary disorders: Hepatitis.
Investigations: Elevated liver enzymes.
Renal and urinary disorders: Dark yellow coloured urine.
Skin and subcutaneous tissue disorders: Pruritus, rash, eczema.
|
|
Drug Interactions
Reduced bioavailability with aluminium hydroxide, magnesium hydroxide or calcium-based antacids. Increased risk of enterocolic events with antibiotics (e.g. amoxicillin/clavulanic acid) and/or chemotherapy. Increased risk of dehydration and hypokalaemia with diuretics. Increased risk of arrhythmia with cardiac glycosides (e.g. digitoxin, digoxin).
|
|
ATC Classification
M01AX21 - diacerein ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
|
Sign Out
