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Administration
Tab: May be taken with or without food.
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Special Precautions
Patient with CV disease (e.g. arrhythmias, hypertension, ischaemic heart disease), prostatic hyperplasia and/or genitourinary obstruction, pyloroduodenal obstruction (e.g. stenotic peptic ulcer), history of asthma or lower respiratory tract symptoms, seizure disorders, thyroid dysfunction, increased intraocular pressure or angle-closure glaucoma. Hepatic impairment. Children and elderly. Pregnancy and lactation. Patient Counselling This drug may cause CNS depression (e.g. drowsiness, impaired mental alertness), if affected, do not drive or operate machinery. Monitoring Parameters Monitor for anticholinergic side effects (e.g. confusion, constipation).
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Adverse Reactions
Significant: Sedation; excitation in children.
Cardiac disorders: Tachycardia.
Eye disorders: Blurred vision.
Gastrointestinal disorders: Dry mouth, epigastric distress.
General disorders and administration site conditions: Lassitude.
Metabolism and nutrition disorders: Anorexia.
Musculoskeletal and connective tissue disorders: Muscular weakness.
Nervous system disorders: Dizziness, headache.
Psychiatric disorders: Nervousness, restlessness, insomnia (especially in children).
Renal and urinary disorders: Difficult or painful urination.
Respiratory, thoracic and mediastinal disorders: Thickening of bronchial secretions, dry nose and throat.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Hypotension.
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Drug Interactions
May mask the warning symptoms of ototoxicity by ototoxic drugs (e.g. aminoglycoside antibiotics). May potentiate the effects of anticholinergic drugs (e.g TCAs) and antiparkinsonian drugs (e.g. trihexyphenidyl). May enhance the effects of CNS depressants (e.g. narcotic analgesics, barbiturates).
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CIMS Class
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ATC Classification
R06AA11 - dimenhydrinate ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines.
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