|
Administration
May be taken with or without food.
|
|
Contraindications
Cardiac failure, coronary artery disease, history of CVA, HTN, psychosis or severe personality disorders. Patients receiving metronidazole, paraldehyde, alcohol or alcohol-containing preparations (e.g. cough syrups, tonics), alcohol-based topical preparations.
|
|
Special Precautions
Patient w/ DM, epilepsy, resp disorders, cerebral damage, hypothyroidism, abnormal EEG results, multiple drug dependence. Renal and hepatic impairment. Pregnancy and lactation. Patient Counselling Do not take alcohol (including alcohol-containing preparations) for up to 14 days after discontinuation. This drug may cause drowsiness or fatigue, if affected, do not drive or operate machinery. Monitoring Parameters Monitor LFTs (baseline and follow-up every 10-14 days), CBC and serum chemistries.
|
|
Adverse Reactions
Drowsiness, fatigue, garlic-like or metallic aftertaste, GI upsets, body odour, halitosis, headache, impotence, acneiform or allergic dermatitis, peripheral and optic neuropathies, psychotic reactions. Disulfiram-alcohol reaction (manifested by flushing of the face, throbbing in the head and neck, pulsating headache, resp difficulties, nausea, copius vomiting, sweating, thirst, chest pain, tachycardia, palpitations, marked hypotension, giddiness, weakness, blurred vision, confusion, and in severe cases, resp depression, CV collapse, cardiac arrhythmias, MI, acute heart failure, unconsciousness, convulsions, and sudden death). Rarely, blood dyscrasias.
Potentially Fatal: Severe hepatitis and/or hepatic failure. |
|
Drug Interactions
Enhances the effects of phenytoin, theophylline and coumarin anticoagulants. Inhibits the metabolism and excretion of rifampicin. Inhibits the metabolism of certain benzodiazepines (e.g. chlordiazepoxide, diazepam). Increased incidence of confusion and behavioural changes w/ isoniazid. May potentiate organic brain syndrome and choreoatphetosis w/ pimozide. Amitryptyline and chlorpromazine may increase the intensity of disulfiram-alcohol reaction.
|
|
ATC Classification
P03AA04 - disulfiram ; Belongs to the class of sulfur-containing agents used as ectoparasiticides.
N07BB01 - disulfiram ; Belongs to the class of drugs used in the management of alcohol dependence. |
Sign Out
