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Contraindications
Phaeochromocytoma, insulinoma. Glucagonoma (use as a diagnostic aid).
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Special Precautions
Patient with adrenal insufficiency, cardiac disease, chronic hypoglycaemia, alcohol induced hypoglycaemia. Patient subjected to starvation or fasting. Glucagonoma, diabetes mellitus (use as diagnostic aid). Neonates, children, and elderly. Pregnancy and lactation. Patient Counselling This drug may cause infrequent hypoglycaemia particularly following diagnostic procedures, if affected, do not drive or operate machinery; or until oral carbohydrates have been consumed. Monitoring Parameters Monitor blood pressure, blood glucose, ECG, heart rate, and mentation. Assess for signs and symptoms of hypersensitivity reactions.
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Adverse Reactions
Significant: Anaphylactic shock, rash (accompanied by hypotension and respiratory difficulties); secondary hypoglycaemia (patient with glucagonoma); elevated blood glucose followed by rebound hypoglycaemia, hypertension; short-term hyperglycaemia. Rarely, necrolytic migratory erythema (continuous infusion).
Gastrointestinal disorders: Abdominal pain, nausea, vomiting.
General disorders and administration site conditions: Inj site reactions.
Respiratory, thoracic and mediastinal disorders: Upper respiratory tract irritation (intranasal).
Potentially Fatal: Increased myocardial oxygen demand, blood pressure, and pulse rate (patient with cardiac disease in cases when used as a diagnostic aid). |
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Drug Interactions
Increased heart rate and blood pressure with β-blockers. May diminish the therapeutic effect or cause paradoxical hypoglycaemia with indometacin. May increase the risk of gastrointestinal adverse reactions with anticholinergic agents. Attenuated therapeutic effect with insulin. May enhance the anticoagulant effect of warfarin.
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CIMS Class
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ATC Classification
H04AA01 - glucagon ; Belongs to the class of glycogenolytic hormones. Used in the treatment of hypoglycemia.
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