Ivermectin

Should be taken on an empty stomach. Take on an empty stomach.

Hypersensitivity.

Patient with loiasis (heavy infection of Loa loa); hyperreactive onchodermatitis (sowda). Immunocompromised (including HIV-infected) patients. No activity against adult Onchocerca volvulus parasites. Severe hepatic impairment (topical cream). Children. Pregnancy and lactation. Patient Counselling Topical: Avoid contact with eyes and lips. Monitoring Parameters Evaluate pregnancy status before use in patients who may become pregnant. Assess for loiasis before and after therapy (especially in patients with significant exposure to Loa loa endemic areas of West and Central Africa). Obtain skin and eye microfilarial counts; periodic ophthalmologic exams. Perform follow-up stool examination (for intestinal strongyloidiasis).

Significant: Mazzotti reaction (e.g. lymphadenitis, oedema, arthralgia, synovitis, tachycardia, fever, pruritus, urticaria) and ophthalmic reaction particularly in patients undergoing treatment for onchocerciasis; transient aggravation of rosacea (topical cream). Blood and lymphatic system disorders: Transient eosinophilia, leucopenia, anaemia. Eye disorders: Conjunctival haemorrhage (if treated for onchocerciasis); conjunctivitis, ocular hyperaemia, eye irritation (topical lotion). Ear and labyrinth disorders: Vertigo. Gastrointestinal disorders: Abdominal pain, constipation, diarrhoea, nausea, vomiting. General disorders and administration site conditions: Asthenia, fatigue. Investigations: Increased AST, ALT, and bilirubin. Metabolism and nutrition disorders: Anorexia. Nervous system disorders: Dizziness, tremor, seizures. Psychiatric disorders: Somnolence. Respiratory, thoracic and mediastinal disorders: Worsening of bronchial asthma. Skin and subcutaneous tissue disorders: Rash, Stevens-Johnson syndrome, toxic epidermal necrolysis (oral); dandruff (topical lotion); skin burning sensation, irritation, pruritus, dry skin (topical cream/lotion). Vascular disorders: Orthostatic hypotension.
Potentially Fatal: Rarely, encephalopathy (especially if the patient with onchocerciasis is co-infected with Loa loa).

Rarely, increased INR with warfarin.

Anthelmintics / Other Dermatologicals

D11AX22 - ivermectin ; Belongs to the class of other dermatologicals.
P02CF01 - ivermectin ; Belongs to the class of avermectine agents. Used as antinematodal.