Latanoprost

Active intraocular inflammation, active herpes simplex keratitis; history of recurrent herpetic keratitis associated with prostaglandin analogues.

Patient with history of herpes simplex keratitis; aphakia, pseudophakia with torn posterior lens capsule or anterior chamber lenses; risk factors for cystoid macular oedema, predisposition for or history of intraocular inflammation (e.g. iritis or uveitis); chronic angle closure glaucoma, pigmentary glaucoma, congenital glaucoma, inflammatory glaucoma, neovascular glaucoma, acute attacks of closed-angle glaucoma; asthma. Use during peri-operative period of cataract surgery. Pregnancy and lactation. Patient Counselling This drug may cause transient blurring of vision, if affected, do not drive or operate machinery. Remove contact lenses prior to administration and reinsert them after 15 minutes. Monitoring Parameters Monitor IOP. Regularly assess patients who develop noticeably increased iris pigmentation.

Significant: Reactivation of herpes simplex keratitis; intraocular inflammation, macular oedema (including cystoid macular oedema); increased brown pigmentation of iris and eyelid skin; eyelash and vellus hair changes (e.g. increase in number, length, thickness and pigmentation; misdirected growth of eyelashes); bacterial keratitis (when multiple-dose container used is inadvertently contaminated). Eye disorders: Mild to moderate conjunctival hyperaemia, eye irritation (e.g. itching, grittiness, burning, stinging and foreign body sensation); punctate keratitis (mostly without symptoms), blepharitis, conjunctivitis; eyelid oedema, localised skin reaction on the eyelids, photophobia, blurred vision, eye pain. Musculoskeletal and connective tissue disorders: Myalgia, arthralgia. Nervous system disorders: Dizziness, headache. Respiratory, thoracic and mediastinal disorders: Dyspnoea. Rarely, exacerbation of asthma. Skin and subcutaneous tissue disorders: Rash.

May cause paradoxical elevations in IOP when used concomitantly with prostaglandins or other prostaglandin analogues or derivatives.

Antiglaucoma Preparations

S01EE01 - latanoprost ; Belongs to the class of prostaglandin analogues. Used in the treatment of glaucoma.