Lomustine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Contraindications Special Precautions Adverse Reactions Pregnancy Category (US FDA) Overdosage Drug Interactions Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

Should be taken on an empty stomach. Take on an empty stomach. May be taken at bedtime to reduce occurrence of nausea.

Contraindications

Previous failure of tumour response to other nitrosoureas; severe bone marrow depression, coeliac disease or wheat allergy. Severe renal impairment. Pregnancy and lactation. Concomitant use with yellow fever vaccine or other live vaccines in immunosuppressed patients.

Special Precautions

Patient with baseline <70% of carbon monoxide diffusing capacity or predicted forced vital capacity (FVC). Renal and hepatic impairment. Monitoring Parameters Monitor CBC with differential and platelet count every week for at least 6 weeks after a dose; liver, renal, and pulmonary function tests at baseline and periodically thereafter. Assess for signs and symptoms of abnormal bleeding and infection.

Adverse Reactions

Significant: Gastrointestinal toxicity (e.g. moderate emesis, stomatitis), hepatotoxicity (e.g. increased transaminases, alkaline phosphatase, and bilirubin), pulmonary toxicity (e.g. infiltrates, fibrosis), nephrotoxicity (e.g. progressive renal failure with decreased kidney size); secondary malignancies, including leukaemia and myelodysplasia (prolonged use). Blood and lymphatic system disorders: Anaemia. Eye disorders: Blindness, optic atrophy, visual disturbances. Gastrointestinal disorders: Nausea, diarrhoea. General disorders and administration site conditions: Ataxia, lethargy. Metabolism and nutrition disorders: Anorexia. Nervous system disorders: Abnormal coordination. Psychiatric disorders: Disorientation, dysarthria, confusion. Renal and urinary disorders: Azotaemia. Skin and subcutaneous tissue disorders: Alopecia.
Potentially Fatal: Delayed bone marrow suppression.

Pregnancy Category (US FDA)

Drug Interactions

May potentiate bone marrow toxicity with theophylline and cimetidine. May reduce the anti-tumour effects with phenobarbital.

CIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01AD02 - lomustine ; Belongs to the class of alkylating agents, nitrosoureas. Used in the treatment of cancer.

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