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Administration
May be taken with or without food.
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Special Precautions
Pregnancy and lactation. Not recommended for prolonged use and higher doses in patients with regular exposure to Hg or its compounds. Monitoring Parameters Megaloblastic anaemia: Monitor CBC, platelet count, reticulocyte count, folate, Fe; vitamin B12 level, serum K.
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Adverse Reactions
Significant:Anaphylactic reactions (inj) (e.g. dyspnoea, hypotension); hypokalaemia, thrombocytosis.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea.
General disorders and administration site conditions: Pain or induration at inj site; feeling hot, diaphoresis.
Metabolism and nutrition disorders: Loss of appetite.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash.
Potentially Fatal: Anaphylactic shock (inj). |
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Drug Interactions
Reduced absorption with colchicine, metformin, neomycin, para-aminosalicyclic acid, chloramphenicol, K chloride, histamine H2 antagonists, and omeprazole. Decreased enterohepatic reabsorption with colestyramine and colestipol. Decreased serum concentration with oral contraceptives.
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ATC Classification
B03BA05 - mecobalamin ; Belongs to the class of vitamin B12 (cyanocobalamin and analogues). Used in the treatment of anemia.
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