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Contraindications
Hypersensitivity, hypertension, preeclampsia. Pregnancy.
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Special Precautions
Patient with sepsis, coronary artery disease (CAD), obliterative vascular disease. Use during the second stage of labour. Renal and hepatic impairment. Lactation. Monitoring Parameters Monitor blood pressure, CNS status, and vaginal bleeding.
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Adverse Reactions
Significant: Hypertension, myocardial ischaemia, MI; ergotism, pleural fibrosis, retroperitoneal fibrosis (prolonged use).
Cardiac disorders: Chest pain, bradycardia, tachycardia, palpitation, coronary arterial spasm.
Ear and labyrinth disorders: Tinnitus.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain.
Immune system disorders: Anaphylaxis.
Metabolism and nutrition disorders: Water intoxication.
Musculoskeletal and connective tissue disorders: Leg cramps.
Nervous system disorders: Dizziness, headache, dysgeusia, seizure.
Psychiatric disorders: Hallucination.
Renal and urinary disorders: Haematuria.
Respiratory, thoracic and mediastinal disorders: Dyspnoea, nasal congestion.
Skin and subcutaneous tissue disorders: Rash, diaphoresis.
Vascular disorders: Vasoconstriction, vasospasm, thrombophlebitis., hypotension.
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Drug Interactions
Increased risk of ergot toxicity with CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, ritonavir, delavirdine, ketoconazole, itraconazole, voriconazole). Enhance vasoconstrictive effect with β-blockers. Diminished therapeutic effect with anaesthetics (e.g. halothane, methoxyflurane). Reduced therapeutic effect of glyceryl trinitrate and other antianginal medications.
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CIMS Class
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ATC Classification
G02AB01 - methylergometrine ; Belongs to the class of ergot alkaloids. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
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