Methylphenidate: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Contraindications Special Precautions Adverse Reactions Overdosage Drug Interactions Food Interaction Lab Interference Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

Methylphenidate (concerta): May be taken with or without food. Swallow whole, do not divide/chew/crush.
Methylphenidate (ritalin): Should be taken on an empty stomach. Take 30-45 min before meals.

Contraindications

History of marked anxiety, tension, agitation; glaucoma; hyperthyroidism; anorexia; phaeochromocytoma; tics or family history or diagnosis of Tourette's syndrome. Pre-existing CV disorders (e.g. severe HTN, heart failure, angina, MI, arrhythmia); aneurysm; vascular abnormalities. Concomitant or w/in 14 days of MAOI use.

Special Precautions

Patient w/ history of seizure disorder, alcohol or drug abuse. HTN and other CV disorders that might be exacerbated by increases in BP or heart rate; pre-existing psychosis or bipolar disorder. Childn. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness and visual disturbances, if affected, do not drive or operate machinery. Avoid exposure of application site to any direct external heat source (TTS). Monitoring Parameters Monitor pulse, BP, psychiatric symptoms, appetite, wt and height prior to initiation, every dose adjustment and at least 6 mthly. Periodic CBC w/ differential and platelet count during prolonged therapy. Monitor for blisterings or oedema which does not improve w/in 48 hr of patch removal, or spreads beyond patch site.

Adverse Reactions

Abdominal pain, aggression, alopecia, anorexia, arrhythmias, arthralgia, asthenia, changes in BP, cough, depression, diarrhoea, dizziness, dry mouth, dyspepsia, fever, growth restriction, headache, insomnia, irritability, movement disorders, nasopharyngitis, nausea, nervousness, palpitation, pruritus, rash, wt loss, tachycardia, tics, vomiting, confusion, abnormal dreams, constipations, dyspnoea, epistaxis, muscle cramps, suicidal ideation, urinary frequency. Rarely, angina, sweating, visual disturbances, cerebral arteritis, blood disorders, angle-closure glaucoma, seizures, tolerance, MI. Transdermal: Insomnia, decreased appetite; nausea; tic, emotional instability; vomiting, anorexia; nasal congestion, nasopharyngitis; wt loss.

Drug Interactions

May reduce effects of antihypertensive agents. May increase serum levels of phenytoin, TCAs. Risk of sudden BP increase during surgery w/ halogenated anaesth. May enhance the adverse/toxic effects of clonidine.

CIMS Class

Other CNS Drugs & Agents for ADHD

ATC Classification

N06BA04 - methylphenidate ; Belongs to the class of centrally-acting sympathomimetics. Used as CNS stimulant.

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