Prazosin: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Special Precautions Adverse Reactions Pregnancy Category (US FDA) Overdosage Drug Interactions Lab Interference Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

May be taken with or without food. Starting dose is best taken w/ dinner, at least 2-3 hr before retiring. Maintenance doses may be taken w/ or w/o meals.

Special Precautions

Patient with history of micturition syncope in the treatment of benign prostatic hyperplasia (BPH); CHF due to mechanical obstruction (e.g. aortic valve stenosis, mitral valve stenosis, pulmonary embolism, restrictive pericardial disease); ischaemic heart disease. Cataract surgery patient. Hepatic and moderate to severe renal impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness or weakness, if affected, do not drive or operate machinery. Monitoring Parameters Rule out prostate cancer before initiation of therapy. Monitor blood pressure and cardiac status.

Adverse Reactions

Significant: Syncope (with sudden loss of consciousness), orthostatic hypotension, priapism, prolonged erections, angina, CNS depression, intraoperative floppy iris syndrome. Cardiac disorders: Palpitations. Ear and labyrinth disorders: Vertigo. Eye disorders: Blurred vision. Gastrointestinal disorders: Diarrhoea, nausea, vomiting, dry mouth, constipation. General disorders and administration site conditions: Oedema, lack of energy, weakness. Nervous system disorders: Headache, dizziness, drowsiness, faintness. Psychiatric disorders: Depression, nervousness. Respiratory, thoracic and mediastinal disorders: Dyspnoea, nasal congestion. Skin and subcutaneous tissue disorders: Rash.

Pregnancy Category (US FDA)

Drug Interactions

May cause symptomatic hypotension with phosphodiesterase type-5 (PDE-5) inhibitors (e.g. sildenafil, tadalafil, vardenafil). Additive hypotensive effect with diuretics or other antihypertensive agents.

CIMS Class

Other Antihypertensives

ATC Classification

C02CA01 - prazosin ; Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.

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