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Contraindications
Hypersensitivity to prulifloxacin or other quinolone antibacterials. Coeliac disease, anamnesis of tendon diseases related to the administration of quinolones. Children or adolescents below 18 years with uncomplicated skeletal development. Pregnancy and lactation. Concomitant use with fenbufen or flurbiprofen.
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Special Precautions
Patient with CNS disorders that may predispose to convulsion or lower the convulsion threshold; remarkably low stomach acid state (e.g. achlorhydria), hypokalaemia, hypocalcaemia, rhythm disorders, latent or known G6PD deficiency. Renal impairment. Patient Counselling Avoid excessive exposure to sunlight or UV rays. Maintain adequate water balance.
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Adverse Reactions
Significant: Phototoxicity, shock or anaphylactoid reaction, crystalluria, hypoglycaemia, pseudomembranous colitis. Rarely, rhabdomyolysis and rapid deterioration of renal function.
Ear and labyrinth disorders: Impaired hearing.
Eye disorders: Ocular hyperaemia.
Gastrointestinal disorders: Abdominal pain, altered taste, epigastralgia, nausea, diarrhoea, gastritis, vomiting.
General disorders and administration site conditions: Fever.
Investigations: Increased AST/ALT.
Metabolism and nutrition disorders: Anorexia.
Musculoskeletal and connective tissue disorders: Muscle spasms.
Nervous system disorders: Cephalalgia, dizziness, drowsiness, lightheadedness.
Psychiatric disorders: Sleep disorders.
Skin and subcutaneous tissue disorders: Pruritus, rash.
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Drug Interactions
May enhance the effects of theophylline. May reduce absorption with antacids containing Al or Mg, Fe or Ca preparations, H2-receptor antagonists (e.g. cimetidine), PPIs (e.g. omeprazole).
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CIMS Class
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ATC Classification
J01MA17 - prulifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
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