Pyridoxine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Special Precautions Adverse Reactions Pregnancy Category (US FDA) Drug Interactions Lab Interference Action Storage CIMS Class

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

May be taken with or without food. Best taken w/ food & liqd. Consult product literature for specific instructions. ER tab: Swallow whole, do not break/crush/chew.

Special Precautions

Children. Pregnancy and lactation. Patient counselling If you develop tingling, burning, or numbness in the hands or feet during treatment, inform your doctor immediately. Monitoring Parameters Closely monitor for signs and symptoms of peripheral neuropathy. Consider performing nerve conduction velocity tests every 1-2 years in patients receiving long-term higher doses.

Adverse Reactions

Significant: Severe peripheral neuropathies, particularly during long-term use and/or use of high doses (risk may vary between individuals; there have been reported cases of peripheral neuropathy even with doses <50 mg/day); drug dependence and withdrawal (for doses ≥200 mg/day). Gastrointestinal disorders: Nausea. Immune system disorders: Hypersensitivity reaction. Investigations: Increased serum AST, decreased serum folic acid levels. Metabolism and nutrition disorders: Metabolic acidosis (particularly in patients with seizures following rapid infusion of high doses). Nervous system disorders: Headache, paraesthesia, drowsiness; seizure (very high IV doses).

Pregnancy Category (US FDA)

Drug Interactions

May reduce the serum levels of phenobarbital and phenytoin. May reduce the effect of levodopa (when concurrently used without a dopa-decarboxylase inhibitor) and altretamine. Oral contraceptives (e.g. estrogen), cycloserine, penicillamine, isoniazid and hydralazine may increase the requirements for pyridoxine.

CIMS Class

Vitamin B-Complex / with C

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