|
Administration
Should be taken with food.
|
|
Contraindications
Active peptic ulcer or ulcerative colitis; history of mental depression; phaeochromocytoma, Parkinson's disease. Patient receiving electroconvulsive therapy (ECT).
|
|
Special Precautions
Patient w/ MI, cardiac arrhythmias, gallstones, epilepsy, allergic conditions (e.g. bronchial asthma). Hypertensive patient w/ renal insufficiency. Pregnancy and lactation. Monitoring Parameters Assess/monitor BP and cardiac status prior to starting therapy, during first doses, when changing dose and regularly, thereafter.
|
|
Adverse Reactions
Nasal congestion, headache, CNS symptoms including depression, drowsiness, dizziness, lethargy, nightmares; GI disturbance including diarrhoea, abdominal cramps, increased gastric acid secretion; flushing, bradycardia, extrapyramidal effects, hypotension, convulsion, breast engorgement, galactorrhoea, gynaecomastia, increased prolactin concentrations, decreased libido, impotence, Na retention, oedema, decreased or increased appetite, wt gain, miosis, dry mouth, sialorrhoea, dysuria, rashes, pruritus, thrombocytopenic purpura.
|
|
Drug Interactions
Enhanced hypotensive effects w/ thiazide diuretics and other antihypertensives. May cause excitation and HTN in patients receiving MAOIs. Risk of cardiac arrhythmias w/ digitalis or quinidine. May enhance the effects of CNS depressants. May inhibit the action of indirect-acting amines (e.g. ephedrine). May prolong the action of direct-acting amines (epinephrine). Decreased antihypertensive effect w/ TCAs.
|
|
CIMS Class
|
|
ATC Classification
C02AA02 - reserpine ; Belongs to the class of rauwolfia alkaloids, centrally-acting antiadrenergic agents. Used in the treatment of hypertension.
|
Sign Out
