Streptokinase

Existing or recent internal haemorrhage, intracranial neoplasm or other neoplasms with risk of haemorrhage, arteriovenous malformation or aneurysm, recent CVA, recent head trauma, intracranial or intraspinal surgery, known haemorrhagic diathesis, spontaneous fibrinolysis and extensive clotting disorders, severe uncontrolled hypertension (>200 mmHg systolic values, >100mmHg diastolic values), hypertensive retinopathy, endocarditis or pericarditis, acute pancreatitis, recent major operation (6th-10th post-operative day), recent invasive operation (e.g. recent organ biopsy, closed chest cardiac massage, implantation of a vessel prosthesis). Severe hepatic and renal impairment. Pregnancy. Recent or concomitant anticoagulant therapy (INR >1.3).

Patient with severe arteriosclerotic vessel degeneration, cerebrovascular disease, recent severe gastrointestinal bleeding (e.g. active peptic ulcer), increased risk of left heart thrombus (e.g. mitral valve defect, atrial fibirillation), open tuberculosis or severe bronchitis, diabetic haemorrhagic retinopathy, septic thrombophlebitis. Recent intubation, trauma and cardiopulmonary resuscitation; previous puncture of non-compressible vessels; undergoing translumbar aortography; with indwelling urethral catheter; obstetrical delivery or operation (including miscarriage); aortic dissection, and any other condition in which bleeding poses a hazard or would cause difficult management due to location. Elderly. Lactation. Monitoring Parameters Monitor blood pressure, heart rate, ECG, PT/INR, aPTT, CBC, and fibrinogen levels. Assess for signs of bleeding.

Significant: Coronary thrombolysis; hypotension, tachycardia and/or bradycardia during initial infusion. Rarely, anaphylactic reactions. Cardiac disorders: Angina pectoris, heart failure, reinfarction, cardiogenic shock, pericarditis. Gastrointestinal disorders: Nausea, vomiting, diarrhoea, epigastric pain, gastrointestinal bleeding. General disorders and administration site conditions: Injection site bleeding, ecchymoses, chills, fevers, asthenia, malaise. Immune system disorders: Antistreptokinase antibody development. Musculoskeletal and connective tissue disorders: Musculoskeletal pain. Nervous system disorders: Headache. Renal and urinary disorders: Genitourinary bleeding. Respiratory, thoracic and mediastinal disorders: Pulmonary oedema.
Potentially Fatal: Haemorrhage.

Increased risk of haemorrhage with drugs that inhibit platelet function (e.g. platelet aggregation inhibitors, dextrans).

Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)

B01AD01 - streptokinase ; Belongs to the class of enzymes. Used in the treatment of thrombosis.