Trihexyphenidyl: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Special Precautions Adverse Reactions Pregnancy Category (US FDA) Overdosage Drug Interactions Food Interaction Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

Should be taken with food. Best taken w/ meals. Take before meals if dry mouth occurs, after meals if drooling/nausea occurs. Take at the same time each day.

Special Precautions

Patient w/ arteriosclerosis, history of drug idiosyncrasy. CV disease, glaucoma, GI obstruction, prostatic hyperplasia and/or urinary stricture. Not intended for treatment of tardive dyskinesia. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair mental or physical abilities e.g. operating machinery or driving. Monitoring Parameters Perform gonioscopic examination prior to initiation of therapy. Monitor intraocular pressure at regular intervals during prolonged treatment.

Adverse Reactions

Dryness of the mouth, nausea, constipation, vomiting, dizziness, drowsiness, headache, blurred vision, mydriasis, nervousness, tachycardia, urinary hesitancy or retention, increased intraocular tension, angle-closure glaucoma, weakness, rashes, dilatation of the colon, paralytic ileus, and suppurative parotitis. Rarely, psychiatric disturbances (e.g. delusion, amnesia, depersonalization, sense of unreality, paranoia).

Pregnancy Category (US FDA)

Drug Interactions

Increased antimuscarinic side effects w/ phenothiazines, clozapine, antihistamines, disopyramide, nefopam and amantadine. Synergistic effect when concomitantly used w/ TCAs. Concurrent admin w/ MAOIs may cause dry mouth, blurred vision, urinary hesitancy or retention and constipation. May antagonise effect of metoclopramide and domperidone on GI function. Reduced absorption of levodopa. May antagonise effect of parasympathomimetics.

CIMS Class

Antiparkinsonian Drugs

ATC Classification

N04AA01 - trihexyphenidyl ; Belongs to the class of tertiary amines anticholinergic agents. Used in the management of Parkinson's disease.

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