Urea

Severely impaired renal function, marked dehydration, frank liver failure. Pulmonary congestion or pulmonary oedema, active intracranial bleeding, heart failure. Sickle cell disease with signs and symptoms of CNS involvement.

Mild to moderate renal or hepatic impairment. Inject into large veins and do not infuse into veins of lower limbs of elderly patients to reduce the risk of thrombosis and phlebitis. Be careful to prevent extravasation. Reduce risk of haemolysis by using glucose or invert sugar solutions as diluent and avoid rapid inj. Do not stop infusion abruptly. Maintain adequate hydration and keep patient horizontal to decrease side effects. Monitor renal function and watch for signs of fluid and electrolyte imbalance. Rebound increase in intracranial and intraocular pressure may occur after 12 hr. Topical applications may be irritant to sensitive skin.

Venous thrombosis or phlebitis at inj site; haemolysis; sloughing or necrosis due to extravasation; fluid and electrolyte imbalance; hypersensitivity reactions; pulmonary oedema. Headache, nausea, vomiting, syncope, disorientation, dizziness, agitation, mental confusion, nervousness, hypotension, tachycardia, cardiotoxicity, hyperthermia.

topical paste & nail lacquer

Increased excretion of lithium.

Diuretics / Keratolytics