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Antipyrine and cimetidine clinical interaction studies indicate that the co-administration of ARIMIDEX with other drugs is unlikely to result in clinically significant drug interactions mediated by cytochrome P450.
A review of the clinical trial safety database did not reveal evidence of clinically significant interaction in patients treated with ARIMIDEX who also received other commonly prescribed drugs.
Tamoxifen and/or other therapies containing oestrogen should not be co-administered with ARIMIDEX, as they may diminish its pharmacological action (see Contraindications).
