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May caused addiction.
Not recommended to use as a monotherapy in patients with depression or anxiety related to depression.
It is not recommended to drive or operate machine during therapy with this drug.
Conduct close monitoring for usage to pregnant and breastfeeding women, patients with chronic liver and renal disease, respiratory disease, muscle weakness and history of drug or alcohol abuse, patients with the real personality disorder.
The safety for usage in children under 10 years has not been assured yet.
Reduce the dose for elders and debilitated patients.
Avoid long-term therapy with this drug.
