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Instructions for Use/Handling: Each applicator is applied directly from the specially designed sealed applicator into the vaginal. Remove the applicator firmly by the thick end shake down like a thermometer to ensure that the contents are at the thin end. Twist off the tablet and discard. The applicator may be inserted while in a sitting position or when lying on back with the knees bent. Gently insert the thin end of applicator well into the vagina. Press the thick end of the applicator and discard in a waste container. Crinone coats the vaginal mucosa to provide long lasting release of progesterone.