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Pharmacology: Pharmacodynamics: Crinone's pharmacodynamic properties are the same as those of the naturally occurring progesterone with induction of a full secretory endometrium.
Pharmacokinetics: The progesterone vaginal gel is based on a polycarbophil delivery system which attaches to the vaginal mucosa and provides a prolonged release of progesterone for at least 3 days.
Toxicology: Preclinical Safety Data: In rabbits, Crinone was an eye irritant categorized as class IV (minimal effects clearing in <24 hrs), but not a dermal irritant.
A moderate vaginal irritation was found in rabbits after application of 2 mL daily of 8% gel for 5 days.
