Pharmacology: Erdosteine is classified as a mucolytic drug that pharmacologically works as a mucus diluent drug in the bronchi.
In addition, erdosteine is also working as a bronchial mucus dilator which facilitates expectoration also shows its effect as an antagonist to free radical formation and counteracts the action of elastase enzymes. From the results of pharmacological studies, this trait occurs after erdosteine is converted into an active metabolite that have -SH cluster. This metabolite can break down the disulphide group, resulting the decrement to elasticity and viscosity of the mucus and facilitate expectoration. The -SH cluster of these activities are chemically inhibited and become free of metabolism or bonded with alkali.
As a mucilage diluent in acute and chronic respiratory diseases.
Dosivec Capsule: 1 capsule twice or three times daily.
Dosivec Dry syr: Children 15-19 kg: 5 mL (1 tsp) twice daily; Children 20-30 kg: 5 mL (1 tsp) three times daily; Children >30 kg and adult: 10 mL (2 tsp) twice daily.
Administration method: Make a suspension by adding 52 mL of water into the bottle. After reconstitution, the suspension can be used up to 7 days.
At doses exceed the recommended doses (900 mg/day): sweating a lot, vertigo, and flushing were observed.
Patients who are hypersensitive to the product. Patient with hepatic cirrhosis and cyasthionine-synthase enzyme deficiency. Patient with severe renal failure (CrCl <25 mL/min).
Not recommended to use in patient with active peptic disease.
Erdosteine pregnancy safety index has not been established yet, so it is not advisable to use erdosteine during pregnancy and lactation.
In suspension product that contain sucrose should be considered in patients with diabetes or undergo low-calorie diets.
Effects on the ability to drive a vehicle and use the machine: No effects are reported.
Erdosteine pregnancy safety index has not been established yet, so it is not advisable to use erdosteine during pregnancy and lactation.
GI tract disorder during Erdosteine usage. Rare: Headache, dyspnea, the change in tasting sense, urticaria, erythema, and dermatitis.
There is no harmful interaction with other drugs ever observed and Erdosteine may be given together with antibiotics, bronchodilators (theophylline, β2-mimetic, sedative cough agent, etc.)
Store below 30°C. Protected from light exposure.
R05CB15 - erdosteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
Dosivec cap 300 mg
2 × 10's (Rp80,000/boks)
Dosivec dry syr 175 mg/5 mL
60 mL x 1's (Rp35,000/boks)
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