Hypercholesterolemia (type IIa) & endogenous hypertriglyceridemia whether isolated (type IV) or associated (type IIb & III) when response to diet alone has been inadequate, when blood cholesterol level remains high in spite of diet &/or when there is a relating risk factor involved.
Adult 100 mg 3 times daily or 300 mg once daily. Cholesterol >4 g/L after diet May be increased to 100 mg 4 times daily. Once normalized, may reduce dose to 100 mg twice daily. 200 M Adult Initially 1 cap daily. Cholesterol level ≥4 g/L after tight diet 1 cap of Hyperchol 100 mg + 1 cap Hyperchol 200 M daily. May be increased to 400 mg (2 cap of Hyperchol 200 M) daily. Maintenance: 1 cap daily. May increase to 300 mg daily in case of rise in blood cholesterol level.
Interrupt treatment if SGPT level exceeds 100 IU. Consider a different therapy if after several mth (3-6 mth) of treatment no adequate reduction in serum lipid levels are achieved. Regular monitoring of transaminase levels every 3 mth for >12 mth of initial therapy. Avoid hepatotoxic substances eg, perhexillin maleate & MAOI. Not recommended for pregnant women & nursing mothers.
Reduce dose of anticoagulants to prevent bleeding complications. In concurrent therapy w/ resin, take the resin at an interval of 2 hr prior to Hyperchol. May produce myopathy in concomitant use of fibrate & HMG-CoA reductase inhibitors. Monitor concurrent use w/ oral hypoglycemic agents w/ other fibrate derivatives.
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