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If after several months (3-6 months) of treatment, no adequate reduction in serum lipid levels are achieved, a different therapy (combination or use of a different drug) should be considered. Transient increases in serum transaminases have been reported in some patients, therefore it is recommended to:
Regular monitoring of transaminase levels every 3 months, should be performed for more than 12 months of initial therapy.
Therapy should be discontinued temporarily, if SGPT level rises above 100 IU.
Avoid hepatotoxic substances such as perhexillin maleate and MAOI when using Fenofibrate.
