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Pharmacology: Sucralfate activity as an anti ulcer is a result of the complexes that made by sucralfate and the proteins that form a protecting layer to the ulcer and also protects against gastric acid, pepsin and bile salts.
Sucralfate heals ulcers in 3 ways: 1) Establish a chemical compound that is bound to the central ulcer and form a protective layer. 2) Inhibiting the action of acid, pepsin and bile salts. 3) Inhibit gastric acid diffusion through the film layer of sucralfate-albumin.
Sucralfate may stay for long period of time in the gastrointestinal tract after it has been administered, resulting in long-term drug effects. Sucralfate is slightly absorbed via the gastrointestinal tract that makes this drug with minimal systemic side effects.
