Sucralfate is a chemical complex formed by sucrose octasulfate and polyalumunium hydroxide.
Pharmacology: Sucralfate activity as an anti ulcer is a result of the complexes that made by sucralfate and the proteins that form a protecting layer to the ulcer and also protects against gastric acid, pepsin and bile salts.
Sucralfate heals ulcers in 3 ways: 1) Establish a chemical compound that is bound to the central ulcer and form a protective layer. 2) Inhibiting the action of acid, pepsin and bile salts. 3) Inhibit gastric acid diffusion through the film layer of sucralfate-albumin.
Sucralfate may stay for long period of time in the gastrointestinal tract after it has been administered, resulting in long-term drug effects. Sucralfate is slightly absorbed via the gastrointestinal tract that makes this drug with minimal systemic side effects.
Short-term treatment of duodenal ulcer (No longer than 8 weeks).
Adult: 2 teaspoon (10 ml) four times daily, on empty stomach (an hour before meal or before bedtime). Treatment should remain, unless the results of endoscopic or x-rays examination have shown recovery.
Hypersensitivity to any component of this medication.
Sucralfate should be administered with caution to patients with renal failure or patients on dialysis. Sucralfate usage during pregnancy should be done when absolutely necessary. Sucralfate should be administered with caution in women on lactation. Antacids may be given half an hour before or after sucralfate administration if needed. Safety and effectiveness in children have not been established yet.
Sucralfate usage during pregnancy should be done when absolutely necessary. Sucralfate should be administered with caution in women on lactation.
The occurrence of side effects are very rare, generally reported reactions are constipation and dry mouth. Other complaints are diarrhea, nausea, vomiting, gastrointestinal discomfort, flatulence, pruritus, rash, drowsiness, dizziness, back pain and headache.
Sucralfate may reduce the absorption and bioavailability of these drugs: cimetidine, ciprofloxacin, digoxin, ketoconazole, norfloxacin, phenytoin, ranitidine, tetracycline and theophylline, so these drugs should be administered two hours prior to administration of sucralfate.
Store below 30°C.
Keep out of reach of children.
A02BX02 - sucralfate ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Mucifat oral susp 500 mg/5 mL
100 mL x 1's (Rp45,000/boks)
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