Proclozam Drug Interactions

Generates mutual potential for sharing drugs that depress CNS, alcohol and anti-convulsions.
If given together with valproic acid, it can increase plasma valproic acid levels.
Together with carbamazepine and phenytoin can increase clobazam metabolism to n-desmethyl clobazam.
Clobazam oxidation metabolism can affect disulfiram or cimetidine resulting in an increased plasma benzodiazepine levels.
Anticholinergic effects of other drugs, including atropine and similar drugs, antihistamines and antidepressants can be strengthened.
Patients must be reminded of possible interactions, especially with alcohol, such as the bioavailability of clobazam can increase by 50%.
Use of clobazam together with narcotic analgesics, increases the likelihood of "euphoria", and can bring psychological dependence.
The effects of muscle relaxants and nitrous oxide will be increased by clobazam.