Tetraxim Mechanism of Action

Pharmacology: Pharmacodynamics: Diphtheria and tetanus toxins are detoxified using formaldehyde and then purified.
The poliomyelitis vaccine is obtained from the propagation of poliomyelitis viruses types 1, 2 and 3 on Vero cells, purified, then inactivated using formaldehyde.
The acellular pertussis components (PT and FHA) are extracted from Bordetella pertussis cultures, then purified.
The pertussis toxin (PT) is detoxified by glutaraldehyde and corresponds to the pertussis toxoid (PTxd). The FHA is native.
It has been shown that PTxd and FHA are two components of major importance for protection against pertussis.
After booster vaccination between 5 to 13 years of age, all children developed protective antibody titres against tetanus (> 0.1 IU/mL) and poliomyelitis viruses. Protective antibody titres against diphtheria (> 0.1 IU/mL) were achieved in at least 99.6% of them. Seroconversion rates in pertussis antibodies (titres higher than four-fold the pre-vaccinal titres) are from 89.1% to 98% or PT (EIA) and from 78.7% to 91% for FHA (EIA).