Volteri Dosage & Drug Information

Concise Prescribing Info Bahasa Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Candesartan cilexetil 8 mg, amlodipine 5 mg

Indications/Uses

HTN.

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Dosage/Direction for Use

Adult 1 tab once daily. May increase up to 12 mg candesartan cilexetil & 10 mg amlodipine once daily if necessary. Patient w/ renal dysfunction Starting dose: 2 mg candesartan cilexetil once daily, may be increased up to 8 mg if necessary.

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Overdosage

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Contraindications

History of hypersensitivity to candesartan cilexetil, amlodipine or dihydropyridines. Patients w/ diabetes on aliskiren fumarate except w/ significantly uncontrolled BP despite treatment w/ other antihypertensive therapy. Pregnant women or women having possibilities of being pregnant.

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Special Precautions

History of drug sensitivity. Not indicated as primary drug for treatment of HTN. Patients w/ bilateral or unilateral renal artery stenosis; hyperkalemia. Closely observe patients on hemodialysis, on strict dietary salt restriction, under diuretic therapy, w/ hyponatremia, heart failure; when using other antihypertensives after termination of this drug. Do not administer w/in 24 hr pre-op. Patients engaging operation of machinery involving risk eg, working at a height, operating machinery or driving motor vehicles. Renal/hepatic dysfunction. Not to be administered to nursing mothers. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Angioedema; shock, syncope or unconsciousness; acute renal failure; hyperkalemia; fulminant hepatitis, hepatic dysfunction or jaundice; agranulocytosis, decreased WBC & platelet count; rhabdomyolysis; interstitial pneumonia; hypoglycemia; AV block.

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Drug Interactions

Intensified hypotensive effect w/ β-blockers, nitroglycerin & sildenafil. Elevation of serum K level w/ K-sparing diuretics eg, spirinolactone, triamtelene, eplerenone, K-supplements. Enhanced antihypertensive effect w/ diuretics eg, furosemide, trichloromethiazide. Enhanced blockade of renin-angiotensin system w/ aliskiren fumarate. Lithium toxicity w/ lithium carbonate. Decreased hypotensive effect & aggravated renal function w/ NSAIDs or COX-2 selective inhibitors (indomethacin). Increased blood conc of amlodipine w/ CYP3A4 inhibitors eg, erythromycin, diltiazem, ritonavir, itraconazole. Decreased blood conc of amlodipine w/ CYP3A4 inducers eg, rifampicin. Enhanced antihypertensive effect w/ grapefruit juice. Increased simvastatin AUC. May increase blood conc of tacrolimus.

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Storage

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Description

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Action

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MIMS Class

Angiotensin II Antagonists / Calcium Antagonists

ATC Classification

C09DB07 - candesartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.

Regulatory Classification

Presentation/Packing

Form

Volteri tab

Packing/Price

3 × 10's

Volteri

Manufacturer:

Fahrenheit