Alone or in combination w/ HMG-CoA reductase inhibitors (statins) as adjunctive therapy to diet in patients w/ primary (heterozygous familial & non-familial) hypercholesterolaemia. In combination w/ fenofibrate as adjunctive therapy to diet for reduction of elevated total-C, LDL-C, Apo B & non-HDL-C in patients w/ mixed hyperlipidemia. In combination w/ statin to reduce risk of CV events (CV death, nonfatal MI & stroke, hospitalization for unstable angina or need for revascularization) in patients w/ CHD & history of acute coronary syndrome; HoFH. Reduction of elevated sitosterol & campesterol levels in patients w/ homozygous familial sitosterolaemia.
View Ezetrol overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Combination w/ statin in patients w/ active liver disease or unexplained persistent serum transaminases elevation; in women of childbearing potential; during pregnancy & lactation.
Discontinue use if myopathy is diagnosed or suspected. Perform LFTs prior to initiation of therapy & according to statin recommendations. Not recommended w/ other fibrates. Concomitant use fenofibrate, cyclosporine, warfarin, another coumarin anticoagulant or fluindione. Not recommended in moderate or severe hepatic insufficiency. Pregnancy. Not to be used during lactation. Not recommended in childn <10 yr.
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