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Sedation may be enhanced upon concomitant use of antihistamines in general with central nervous system depressants such as barbiturates, alcohol, hypnotic, opioid analgesics, anxiolytic sedatives and neuroleptics.
The use of cetirizine hydrochloride with drugs that inhibit the cytochrome P-450 microsomal enzymes such as azithromycin, erythromycin and ketoconazole, did not cause clinically significant changes.
Oral drops: Sedative interactions apply to a lesser extent with the non-sedating antihistamines; they do not appear to potentiate the effects of alcohol, but it should be avoided in excess. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs).
