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CNS Depressants (e.g., Alcohol): Avoid concomitant use due to possible additive effect (i.e., additional reduction in alertness, additional impairment of CNS performance).
Ritonavir: Ritonavir disposition is not altered but this may cause increased AUC (42%), increased half-life (53%), and decreased clearance (29%) of cetirizine.
Theophylline: Theophylline disposition is not altered but this may cause decreased clearance (16%) of cetirizine.
Ketoconazole: Concomitant administration with cetirizine caused prolongation of QTc interval (increase of 17.4 msec). However, this interaction was not considered clinically important.
Antipyrine, Azithromycin, Cimetidine, Erythromycin, Ketoconazole, Pseudoephedrine: No clinically important changes in electrocardiogram parameters and no pharmacokinetic interactions were observed with cetirizine.
