Pharmacology: Pharmacokinetics: There is little or no absorption of amphotericin B from the gastrointestinal tract. When given intravenously in the conventional colloidal form and in the usual increasing dosage regimens, peak plasma concentrations of 0.5 to 4 micrograms/mL have been reported; the average plasma concentration with maintenance doses of 400 to 600 micrograms/kg daily tends to be 500 nanograms/mL. Amphotericin B is highly bound to plasma proteins and is widely distributed, but passes into the Cerebrospinal Fluid only in small quantities. The plasma half-life is about 24 hours; with long-term use the terminal half-life increases to 15 days. Unchanged amphotericin B is excreted in small amounts slowly in the urine. Traces are present in the serum and urine several weeks after completion of treatment. Amphotericin B is not removed by haemodialysis.
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