Amphotret Adverse Reactions

amphotericin b

Manufacturer:

Distributor:

Sandoval

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Full Prescribing Info

Adverse Reactions

The adverse effects related to the intravenous administration of amphotericin B include nephrotoxicity, anemia, infusion related adverse events and phlebitis. Nephrotoxicity is a major dose limiting organ toxicity. One manifestation is tubular necrosis. Signs of nephrotoxicity include elevated serum creatinine and blood urea nitrogen, hypokalemia and hypomagnesemia. Amphotericin B nephrotoxicity tends to be reversible, although there is evidence that doses exceeding 4 to 5g place at risk for irreversible changes in renal function.

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