Amso Special Precautions

As with other α1-adrenoceptor antagonists, a reduction in blood pressure can occur in individual cases during treatment with Tamsulosin Hydrochloride (Amso) 400 mcg Capsule, as a result of which, rarely, syncope can occur. At the first sign of orthostatic hypotension (dizziness, weakness), as the patient should sit or lie down until the symptoms have disappeared.
Before therapy with Tamsulosin Hydrochloride (Amso) is initiated, the patient should be examined in order to exclude the presence of other conditions, which can cause the same symptoms as benign prostatic hyperplasia. Digital rectal examination and, when necessary, determination of prostate specific antigen (PSA) should be performed before treatment and at regular intervals afterwards.
Treatment of patients with a history of orthostatic hypotension should be approached with caution.
The treatment of patients with severe renal impairment (creatinine clearance of <10mL/min) should be approached with caution, as these patients have not been studied.
The treatment of patients with severe hepatic dysfunction should be approached with caution.
Interoperative Floppy Iris Syndrome (IFIS, a variant of small pupil syndrome) considered to be due to alpha-1 blocking action has been observed during cataract and glaucoma surgery in same patients on or previously treated with Tamsulosin. Ophthalmologists should be aware of possible occurrence of IFIS during the surgery.
Tamsulosin Hydrochloride (Amso) should be used with caution in combination with strong inhibitors of CYP3A4 (see Interactions and Pharmacology: Pharmacokinetics under Actions). Tamsulosin Hydrochloride (Amso) should not be used in combination with strong inhibitors of CYP3A4 in patients known to be CYP2D6 poor metabolizers.
Cases of allergic reaction to Tamsulosin Hydrochloride (Amso) in patients with a past history of sulfonamide allergy have been reported. If a patient reports a previously experienced sulfa allergy, caution is warranted when administrating Tamsulosin Hydrochloride (Amso).
Effects on Ability to Drive and Use of Machines: No studies on the effects on the ability to drive and use machines have been performed. However, patients should be aware of the fact that dizziness can occur.