Ampicillin + Sulbactam is indicated for infections where beta-lactamase production is suspected. Typical indications are upper and lower respiratory tract infections including sinusitis, otitis media and epiglottitis; bacterial pneumonia; urinary tract infections and pyelonephritis; intra-abdominal infections including peritonitis, cholecystitis, endometritis and pelvic cellulitis; bacterial septicemia; skin; soft tissue, bone and joint infections and gonococcal infections.
It may also be administered pre-operatively to reduce the incidence of post-operative wound infections in patients undergoing abdominal or pelvic surgery, in which peritoneal contamination may be present. In termination of pregnancy or caesarian section, Ampicillin + Sulbactam may be used as prophylaxis to reduce postoperative sepsis.