Sildenafil Citrate is a phosphodiesterase type-5 inhibitor used in the management of erectile dysfunction and pulmonary arterial hypertension.
In erectile dysfunction the usual dose is equivalent to sildenafil 50 mg about one hour before sexual intercourse. The dose may be increased or decreased depending on response. The maximum recommended dose is 100 mg, and sildenafil citrate should not be taken more than once in 24 hours.
In patients stabilised on alpha blocker therapy, an initial dose of sildenafil 25 mg should be considered.
To improve exercise ability in pulmonary arterial hypertension, sildenafil citrate is given orally in a dose of 20 mg three times daily.
Administration in hepatic impairment: Sildenafil Citrate clearance is reduced in patients with hepatic impairment.
Erectile dysfunction: Sildenafil Citrate, an inhibitor of phosphodiesterase type-5, is used as an oral therapy for erectile dysfunction. It is effective in erectile dysfunction of psychogenic causes and organic causes such as diabetes mellitus, spinal-cord injury, and prostatectomy.