Atorvast-Natrapharm Contraindications

Hypersensitivity to atorvastatin calcium or to any component of Atorvast-Natrapharm (see Description).
Active liver disease or unexplained persistent elevations of serum transaminases exceeding 3 times the upper limit of normal (ULN) (see Precautions).
Use in pregnancy: Atorvastatin is contraindicated during pregnancy. Cholesterol and other products of cholesterol biosynthesis are essential components for fetal development (including synthesis of steroids and cell membranes). Atorvastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive and have been informed of the possible harm. If the patient becomes pregnant while taking atorvastatin, the drug should be discontinued immediately and the patient apprised of the potential harm to the fetus. Atherosclerosis being a chronic process, discontinuation of lipid metabolism regulating drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia.